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Exercise Science Lecture Series

Presented in partnership with:
UCI Exercise Medicine Sports Science Initiative
Department of Physiology and Biophysics


Molecular Rescue of Running Behavior in Rats Selectively Bred to Run Low Distances


Monday, March 5, 2018
1:00 PM - 2:00 PM
(Coffee and snacks provided)


UCI Campus - Tampkin Hall
Room F110
Irvine CA 92697

Frank Booth, PhD

Dr. Booth rose to Robert Greer Professor of Integrative Biology and Pharmacology in his 24 years at the University of Texas Medical School at Houston. He has now completed his 17th year as Professor of Biomedical Sciences in the College of Veterinary Medicine at the University of Missouri. Dr. Booth has published 176 peer-reviewed papers and 89 review articles. Of his 253 papers listed on Scopus in the beginning of 2016, 140 contained the word gene; 224 contained the word muscle; and 18 were listed as translational, 99 contained the word health; and 105 listed the word disease. In the middle 1990's, a MD-PhD student in Booth lab convinced Dr. Booth that he should apply his research talents to the mechanisms of exercise benefits that produce health. This led to numerous reviews beginning in 2000. The first two words for my 2000 and 2002 reviews were Waging War on Modern Chronic Diseases and Physical Inactivity, respectively. In 2008, Dr. Booth began a two-way artificial selective breeding of rats exhibiting the phenotype of low or high intrinsic drive for voluntary running. My animal model proves inactivity genes must exist. Currently, Dr. Booth is studying the molecular basis for the inherent genes that cause irreversible declines in cardiovascular fitness and voluntary physical activity from their lifetime apices. A recent unpublished observation showed partial rescue for low voluntary running by AAV-gene transfer into the nucleus accumbens of female rats.