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2016 Robert Newcomb Interdisciplinary Team Science Award
This award was established to highlight and honor individuals who have played a formative role in bringing together teams of researchers from diverse, trans-, multi-, and interdisciplinary backgrounds in studies and projects that have advanced biomedical and clinical research. Bob (Robert) was a quintessential “team player.” His many skills as an athlete and coach, his dedication to teaching, commitment to translational research at UC Irvine, and outstanding leadership in statistical analysis of complex problems uniquely positioned Bob to catalyze and incubate teams of investigators. Nothing was more delightful to Bob than to bring together talented and enthusiastic scientists, students, and staff in pursuit of finding real solutions and discoveries that would advance clinical care and research.
The 90+ Study Team
The 90+ Study was initiated in 2003 to study the oldest-old, the fastest growing age group in the United States. Because little is known about people who achieve this milestone, the remarkable increase in the number of oldest-old presents a public health priority to promote the quality as well as the quantity of life. The 90+ Study Team is led by co-Principal Investigators Dr. Claudia Kawas and Dr. María Corrada. They founded the study in 2002 in close collaboration with Dr. Annlia Paganini-Hill and Dr. Ron Brookmeyer.
The study is among the leading sources of information on the incidence and prevalence, neurobiological and neuropathological substrates, and the risk factors associated with dementia in the oldest old. The knowledge gained through this study is the direct result of extensive collaboration and a long-standing team-science approach. An important component of The 90+ Study is its Autopsy Program where study participants agree to donate their brain for research . The program is done in close collaboration with UCI’s Alzheimer’s Disease Research Center, led by Dr. Frank La Ferla and Dr. Joshua Grill . Dr. Edwin Monuki and Dr. Ron Kim lead the ADRC NeuroPathology Core, generating standardized neuropathological reports from autopsies of study participants and Dr. John Trojanowski, University of Pennsylvania, provides assessments using unique histochemical and immunohistochemical techniques. In addition, Dr. Wayne Poon, coordinator of the ADRCs tissue repository, keeps careful inventory of the available specimens and facilitates sharing of tissue for collaborative projects. Recently, The 90+ Study began their Neuroimaging Program, done in close consultation and collaboration with Dr. Charles DeCarli of UC Davis, as well as Dr. Craig Stark and Dr. Mike Yassa. Studies on vascular aging are led by Dr. Szofia Bullain and Dr. Charles Glabe leads investigations of conformation dependent amyloid antibodies.
The 90+ Study Team has together produced a body of literature that makes up a major source understanding of the risk factors, incidence and prevalence, clinical characteristics, and the neuropathological substrates of dementia in the oldest old. This work has been more than collaborative; it has been synergistic—leading to exploration of unique research topics through consistent availability of data, openness to essentially any collaboration, and ongoing weekly sessions to move collaborative research forward. This collaborative synergy has resulted in a multitude of high-impact papers that clearly make UCI the world’s most recognized center for research on the oldest old.
Register now for the Awards Dinner to be held on June 3; space is limited
The 8th Annual ICTS Awards Dinner