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BRAID CHILD HEALTH: COLLABORATIVE MULTISITE STUDY CATALYTIC FUND

Rationale:

Studies focused on child health almost invariably require multisite designs to ensure that participant accrual and retention goals are met. Cooperation among the UC medical centers and campuses provides a unique opportunity to achieve this goal with the added benefit of coalescing the immense talent and experience among UC child health researchers in a wide range of areas of interest. BRAID-Child Health provides an existing infrastructure to organize, select, and manage this catalytic funding opportunity.

Purpose and Goals:

  1. To provide start-up funding to create the initial team-building, design, statistical analysis, and informatics plans for high-impact multisite studies focused on child health.
  2. To catalyze productive collaborations among child health researchers across the UC system.
  3. To identify key areas in need of development (e.g., pilot data, organizational infrastructure).
  4. To focus on research themes that are consistent with multiple research funding opportunities once the research team is activated
  5. To develop a business/action plan with the goal of securing extramural funding within a 3-5 year period.

 

Requirements:

  1. The proposed research must represent novel, relevant, and high-impact topics in child health.
  2. All five UC medical centers must be involved. The role of each center must be clear and unambiguous.
  3. A campus lead from each site must be identified.
  4. Only a single project leader for the whole 5-campus project should be selected.
  5. A case must be made as to how each site will benefit from the catalytic support
  6. A plan for likely extramural funding opportunities must be sound
  7. Awardees must agree to:
    1. Participate in a team building conference in which an organizational chart and business plan with firm timelines and landmarks are agreed upon
    2. Work with the UCI ICTS in a schedule for monitoring goals and objectives
    3. Develop plans for extramural funding and low-cost preliminary data

 

Organization and funding:

  1. The project leader is Dr. Tina Chambers, Chair of BRAID Child Health
  2. Project and funding administration will be handled by the UC Irvine Institute for Clinical and Translational Science
  3. Applications will be reviewed by experts outside of the UC system

 

Budget:

A brief statement about the general uses of budget should be provided with the application. It is recognized that a more detailed budget will evolve as a result of the initial catalytic meetings. Here are some examples of possible Budget Statements:

Example 1: “Our project involves creating an accessible data base of children who have survived PICU care for severe trauma but went on to develop cognitive, behavioral, or neuromotor longer term sequelae. We will budget to create initial individual interviews with the PICU directors at the five UC health centers and for an inaugural team building conference. At that point we will allocate remaining sources to enhance the development of preliminary data necessary for a multisite grant.”

Example 2: “Our project is focused on assessing executive function in children on renal dialysis across the UC system. We will budget to standardize tests of executive function with the goal of producing a consensus of how to test for executive function in children requiring dialysis. At that point we will budget for a catalytic/team building meeting and we allocate funds for gathering and analyzing data in 50 children.”

Example 3: “Our project is focused on using telehealth techniques to provide exercise training on an individualized basis to children with cystic fibrosis at the five UC health centers. We will budget for a centralized telehealth monitoring system that can easily access video feeds from individual home computers. The remainder of our funds will be used to support a catalytic/team building conference.”

KEY DATES

Applications Due: June 1
Decision: July 15
Earliest Funding: August 1, 2015-July 31, 2016

APPLICATION:
PLEASE SUBMIT YOUR APPLICATION ONLINE AT: http://www1.icts.uci.edu/braid_grants/

 

Arial 11, 0.5 inch margins

Section

Content

Length

Cover Page

Project Title
Key Personnel (at least one from each campus)

1-page

Biosketch

For each key personnel

 

I. Title and Abstract

Brief overview of the key child health research questions, and goals and objectives of the project

30 lines

II. Specific Aims

Describe the aims that would be part of a larger grant, after the catalytic phase has been completed

Single page

III. Significance

  1. Explain the importance of the problem or critical barrier to progress in the field that the proposed project addresses.
  2. Explain how the proposed project will improve scientific knowledge, technical capability, and/or clinical practice in one or more broad fields.
  3. Describe how the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field will be changed if the proposed aims are achieved

1/2-page

Innovation

  1. Explain how the application challenges and seeks to shift current research or clinical practice paradigms.
  2. Describe any novel theoretical concepts, approaches or methodologies, instrumentation or interventions to be developed or used, and any advantage over existing methodologies, instrumentation, or interventions.

1/2-page

Approach

  1. Describe the overall strategy, methodology, and analyses to be used to accomplish the specific aims of the project
  2. Describe any strategy to establish feasibility, and address the management of any high risk aspects of the proposed work.

1/2-page

Role and Contribution of Each UC CTSA

  1. Describe how each campus will contribute to the research
  2. Describe possible benefits obtained from each campus
  3. Organizational chart

1/2-page

Budget

Brief description of how you would propose to use these limited resources to enhance your ability to successfully apply for extramural funding

½ page